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The overall pattern of metabolism was similar in all three species, with tapentadol-glucuronide being the primary metabolite in plasma/serum (accounting for 79-84% of total plasma/serum exposure (AUC)), followed by tapentadol tapentadol catechol-glucuronide (4-10%) and N-desmethyl-tapentadol-glucuronide (4-9%) .
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