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methadone 43 hours . Oxycodone is metabolized in part by cytochrome P450 2D6 to oxymorphone, which represents less than 15% of the methadone drug interactions methadone zombie methadone effects methadone kill you methadone total administered dose . 51 methadone � 1 . 6 However, oxymorphone has a significantly longer half methadone life (7-9 hours)7 than does oxycodone, whose mean elimination half-life following a single, oral dose is 3 .
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