Male contraceptive taken shortly before sex shows promise

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When it comes to contraception, men may finally have a greater choice than a condom or vasectomy, with a study in mice released this week suggesting it may be possible to develop a pill that could be taken shortly before sex.To get more news about vigrx plus near me, you can visit vigrxplus-original.com official website.

With what some have described as a “global epidemic” of unplanned pregnancies, and surveys suggesting many men hold positive views about a potential “male pill”, it seems to be fertile ground.

But with the field littered with false starts, are we really on the brink of a new sexual revolution?As Allan Pacey, professor of andrology at the University of Sheffield, notes, there are number of challenges to developing such contraception.

The biology is very hard,” he said. “We’re having to deal with destroying, stopping the production of, or disabling, millions upon millions of [sperm] cells, as opposed to a single egg [for women],” he said.

What’s more, the tolerance for side-effects is very low for male contraceptives.

“For female contraceptives it is different since the risk of pregnancy is weighed against the risk of contraceptive side-effects,” said Dr Melanie Balbach from Weill Cornell Medicine in New York, adding that another barrier to development of male contraceptives has been the societal view that the burden of contraception falls to the female because they carry the pregnancy.

One problem is that male contraceptives that use hormones to stop sperm production can lower testosterone levels, and hence affect libido.

“Making [a male] contraceptive is quite easy if you’re not bothered about having a libido, but then there’s no point,” said Pacey.

To get around the problem, researchers have added testosterone, or a testosterone-like compound to the contraceptives – an approach that has been trialled in jabs, gels and pills. Although the former hit a glitch with unpleasant side-effects, trials of other methods are going well.

“We completed a second trial and are still working on optimising the dosing of the pill,” said Stephanie Page, a professor of medicine at the University of Washington in Seattle, although she added limited resources for this effort mean the team was also working on the gel.

An alternative approach is rather more mechanical: blocking the tubes that carry sperm from the testicles, with researchers in Australia exploring the use of a hydrogel for the job that would last for two years.

In effect, such an approach would offer a reversible, scalpel-free vasectomy. But Pacey thinks the answer lies elsewhere.

“I’ve always thought that the way we would crack this is if somebody could find a molecule or a receptor or something on sperm that could be disabled in some way,” he said.

The latest study, published in the journal Nature Communications, takes just such an approach, essentially stopping sperm from being able to move by blocking a protein called soluble adenylyl cyclase, or sAC.