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Known to affect a estradiol clot formation Estrace should be used carefully together with warfarin (Coumadin) . Estrogen can inhibit the metabolism of cyclosporine resulting vagifem or ovestin estrofem jak stosować vagifem and smoking side effects of using estrace cream in increase of its levels in blood and kidney and/or liver damage . Estrogen are abler to increase the risk of liver disease in patients treated estradiol by dantrolene . Enhanced metabolism estradiol and excretion of Estrace may be stipulated by rifampin, barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin) and primidone .

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