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tapentadol 64 mg/kg IV and 21 . 5 tapentadol mg/kg IP, resulting in mortality with repeated doses at 15 mg/kg/day IV . AusPAR Palexia SR Tapentadol CSL Ltd PM-2009-02489-3-1 Final 28 February 2011 Page 10 tapentadol injection nucynta janssen depomed tapentadol vs hydromorphone nucynta ulcers tapentadol of 126 Respiratory effects Tapentadol induced effects consistent with respiratory depression in conscious rats (for example, decreased respiratory rate, increased partial pressure of carbon dioxide (pCO2) and decreased partial pressure of oxygen (pO2)) at doses ≥ 4 .
From that point onward, mean pain intensity scores were numerically and consistently lower in the tapentadol SR group tapentadol than in the oxycodone CR group (see Figure 10) .
The comparisons of oxycodone CR and placebo were not tapentadol statistically significant .
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